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KMID : 1143420220150352474
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Public Health Weekly Report
2022 Volume.15 No. 35 p.2474 ~ p.2481
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Management of Young-onset Type 2 Diabetes
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Bae Jae-Hyun
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Abstract
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The incidence and prevalence of young-onset (aged <40 years) type 2 diabetes are increasing globally. Accumulating
evidence suggests that people with young-onset type 2 diabetes have a more aggressive phenotype, with the development of microvascular and macrovascular complications at an early age and premature mortality, compared to those with usualonset or late-onset type 2 diabetes and type 1 diabetes. The rapid deterioration of pancreatic beta-cell function combined with insulin resistance characterizes the pathophysiology of young-onset type 2 diabetes. Modifiable and non-modifiable risk factors, including intrauterine environment, a longer duration of the disease, and traditional cardiovascular risk factors contribute to disease progression and adverse health outcomes. An increase in young-onset type 2 diabetes may impose a considerable disease burden. Therefore, the early recognition of people at risk and effective strategies to prevent or delay the course of young-onset type 2 diabetes are needed.
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KEYWORD
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Disease management, Diabetic complications, Age of onset, Young adult, Diabetes mellitus, type 2
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